Araf Pharmaceuticals
Zylexx Sr Tablets 150Mg
Zylexx Sr Tablets 150Mg
Couldn't load pickup availability
SPECIFICATION
Requires Prescription (YES/NO)
Yes
Generics
Bupropion HCl
Used For
Depression
How it works
Bupropion is a selective inhibitor of the neuronal re-uptake of catecholamines (noradrenaline and dopamine) with minimal effect on the re-uptake of indolamines (serotonin) and does not inhibit either monoamine oxidase. The mechanism of action of bupropion as an antidepressant is unknown. However, it is presumed that this action is mediated by noradrenergic and/or dopaminergic mechanisms.
USAGE AND SAFETY
Dosage
Bupropion HCl
Side Effects
Agitation, dry mouth, insomnia, headache/migraine, nausea/vomiting, constipation, and tremor, taste disorders, dizziness, concentration disturbances.
Drug Interactions
Inhibitors/inducers of the CYP2B6 isoenzyme (e.g., orphenadrine, thiotepa, cyclophosphamide, ticlopidine, and clopidogrel) , paroxetine, sertraline, norfluoxetine, and fluvoxamine as well as nelfinavir and efavirenz , antidepressants (SSRIs, many tricyclics), beta-blockers, antiarrhythmics, and antipsychotics , nortriptyline, imipramine, desipramine, antipsychotics e.g., haloperidol, risperidone, thioridazine , beta-blockers (e.g., metoprolol), antiarrhythmics e.g., propafenone, flecainide , MAO Inhibitors , Levodopa and Amantadine , antipsychotics, other antidepressants, theophylline, systemic steroids, Alcohol.
Indication
It is indicated for the treatment of major depressive episodes.
When not to Use
It is contraindicated in patients with hypersensitivity to bupropion or any of the excipients , In patients with a current seizure disorder or any history of seizures , In patients with a known central nervous system tumour.
PRECAUTIONS
Precaution
All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases.
WARNINGS
Warning 1
The recommended dose of modified release bupropion should not be exceeded, since bupropion is associated with a dose-related risk of seizure.
Warning 2
It should be discontinued promptly if patients experience hypersensitivity reactions during treatment.
Warning 3
There is limited clinical experience of the use of bupropion to treat depression in patients with cardiovascular disease. Care should be exercised if it is used in these patients. However, bupropion was generally well tolerated in studies for smoking cessation in patients with ischaemic cardiovascular disease.
ADDITIONAL INFORMATION
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.