Zolisome reduces the amount of acid your stomach makes. Its widely used to: treat indigestion, heartburn and acid reflux, and gastro-esophageal reflux disease (GERD) – a condition which means you keep getting acid reflux. prevent stomach ulcers.You'll usually take Zolisome once a day, first thing in the morning. You can take it with or without food. If you take Zolisome twice a day, take 1 dose in the morning and 1 dose in the evening. Swallow tablets and capsules whole with a drink of water (non-fizzy).