ICI PAKISTAN LTD
Zestril 5mg Tablets
Zestril 5mg Tablets
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SPECIFICATION
Requires Prescription (YES/NO)
Yes
Generics
Lisinopril
Used For
Hypertension
How it works
Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin converting enzyme (ACE) that catalyses the conversion of angiotensin I to the vasoconstrictor peptide, angiotensin II. Whilst mechanism through which lisinopril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system. Lisinopril is antihypertensive even in patients with low-renin hypertension.
USAGE AND SAFETY
Dosage
Lisinopril
Side Effects
Common: Dizziness, headache, orthostatic effects (including hypotension), cough, diarrhea, nausea, vomiting.Uncommon: Mood alterations, paraesthesia, vertigo, taste disturbance, sleep disturbances, myocardial infarction or cerebrovascular accident, possibly secondary to excessive hypotension in high risk patients, palpitations, tachycardia. Raynaud's phenomenon, rhinitis, abdominal pain and indigestion, rash, pruritus, impotence, fatigue, asthenia, increase in blood urea, increase in serum creatinine, increasein liver enzymes, hyperkalaemia.Rare: Decrease in hemoglobin, decrease in hematocrit, mental confusion, dry mouth, hypersensitivity/angioneurotic edema: angioneurotic edema of the face, extremities, lips, tongue, glottis, and/or larynx, urticaria, alopecia, psoriasis, uraemia, acute renal failure.Very rare: Bone marrow depression, anaemia, thrombocytopenia, leucopenia, neutropenia, agranulocytosis, haemolytic anaemia, lymphadenopathy, autoimmune disease, hypoglycemia, bronchospasm, sinusitis, allergic alveolitis/eosinophilic pneumonia, pancreatitis, intestinal angioedema, hepatitis - either hepatocellular or cholestatic, jaundice and hepatic failure, diaphoresis, pemphigus, toxic epidermal necrolysis, Stevens-Johnson Syndrome, erythema multiforme, oliguria/anuria, gynaecomastia, increase in serum bilirubin, hyponatremia.
Drug Interactions
Diuretics , Potassium supplements, potassium-sparing diuretics (e.g. spironolactone, triamterene or amiloride) or potassium-containing salt substitutes, Lithium , NSAIDs and ACE inhibitors , glyceryl trinitrate and other nitrates , tricyclic antidepressants and antipsychotics , Sympathomimetics , antidiabetic medicines (insulins, oral hypoglycemic agents ) .
Indication
Lisinopril is indicated for: Hypertension : The treatment of hypertension.Heart failure : The treatment of symptomatic heart failure. Acute myocardial infarction : Short-term (6 weeks) treatment of haemodynamically stable patients within 24 hours of an acute myocardial infarction.Renal complications of diabetes mellitus : Treatment of renal disease in hypertensive patients with type 2 diabetes mellitus and incipient nephropathy.
When not to Use
Lisinopril is contraindicated in patients:- With hypersensitivity to lisinopril, to any of the excipients or any other angiotensin converting enzyme (ACE) inhibitor.- With a history of angioedema associated with previous ACE inhibitor therapy.- With hereditary or idiopathic angioedema.- Who are pregnant .
PRECAUTIONS
Precaution
Lisinopril therapy should be immediately discontinued in patients presenting with angioedema; appropriate anti-histamine/corticosteroid therapy and monitoring should be provided until complete and sustained resolution of all signs and symptoms has occurred.
WARNINGS
Warning 1
Occasionally, blood pressure drops too low after taking lisinopril. This usually happens after the first or second dose or when the dose is increased. It is more likely to occur in those who take diuretics, have a salt-restricted diet, are on dialysis, or are suffering from diarrhoea or vomiting. In patients at increased risk of symptomatic hypotension, initiation of therapy and dose adjustment should be closely monitored.
Warning 2
As with all vasodilators, lisinopril should be given with caution to patients with obstruction in the outflow tract of the left ventricle.
Warning 3
In patients undergoing major surgery or during anesthesia with agents that produce hypotension, lisinopril may blockangiotensin II formation secondary to compensatory renin release. If hypotension occurs and is considered to be due to this mechanism, it can be corrected by volume expansion.
ADDITIONAL INFORMATION
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.