Requires Prescription (YES/NO)

Yes

Generics

Lisinopril Dihydrate , Hydrochlorothiazide

Used For

Hypertension

How it works

Lisinopril : The mechanism through which lisinopril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system. Lisinopril is antihypertensive even in patients with low-renin hypertension. Hydrochlorothiazide : The mechanism of the antihypertensive effect of thiazides is unknown. Thiazides do not usually affect normal blood pressure. Hydrochlorothiazide is a diuretic and antihypertensive. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume with consequent increase in plasma renin activity increase in aldosterone secretion, increases in urinary potassium loss and decrease in serum potassium. The renin-aldosterone link is mediated by angiotensin II, so co-administration of an angiotensin II receptor antagonist tends to reverse the potassium loss associated with these diuretics .

Dosage

Lisinopril Dihydrate , Hydrochlorothiazide

Side Effects

Common : Dizziness, headache, dry cough, fatigue, hypotension including orthostatic hypotension. Small decreases in hemoglobin and haematocrit. Less Common : Diarrhea, nausea, vomiting, dry mouth, rash, gout, palpitations, chest discomfort, muscle cramps and weakness, paraesthesia, asthenia and impotence, hyperglycemia, hyperuricemia and hyper or hypokalemia. Rarely : Pancreatitis, agranulocytosis, elevations of liver enzymes and/or serum bilirubin.

Drug Interactions

Agents Increasing Serum Potassium , Agents Affecting Sympathetic Activity , Lithium , Corticosteroids (ACTH) , Nonsteroidal Anti-inflammatory Drugs , Tubocurarine , Insulin , Alcohol, Barbiturates or Narcotics , Pressor Amines .

Indication

It is indicated in the management of mild to moderate hypertension in patients who are not adequately controlled on monotherapy.

When not to Use

Lisinopril+Hydrochlorothiazide is contraindicated in patients who are hypersensitive to any component of this product and in patients with a history of angioneurotic edema relating to previous treatment with an angiotensin-converting enzyme inhibitor and in patients with hereditary or idiopathic angioedema. - Lisinopril+Hydrochlorothiazide is contraindicated in patients who are hypersensitive to other sulphonamide-derived drugs. - Lisinopril+Hydrochlorothiazide is contraindicated in patients with anuria. - Lisinopril+Hydrochlorothiazide is contraindicated in pregnancy and treatment should be stopped if pregnancy is suspected.

Precaution

As with all antihypertensive therapy, symptomatic hypotension may occur in some patients. Periodic determination of serum electrolytes should be performed at appropriate intervals in such patients. In patients at increased risk of symptomatic hypotension, initiation of therapy and dose adjustment should be monitored under close medical supervision .

Warning 1

Particular consideration should be given when therapy is administered to patients with ischemic heart or cerebrovascular disease because an excessive fall in blood pressure could result in a myocardial infarction or cerebrovascular accident.

Warning 2

Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.

Warning 3

Thiazides may decrease urinary calcium excretion and may cause intermittent and slight elevation of serum calcium. Thiazides should be discontinued before carrying out tests for parathyroid function .

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)