Novartis Pharmaceuticals (Pvt) Ltd
Trioptal Tablets 600mg
Trioptal Tablets 600mg
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Trioptal Tablets Specification
Requires Prescription (YES/NO)
Yes
Generics
Oxcarbazepine
Used For
Seizures
How it works
The pharmacological activity of oxcarbazepine is primarily exerted through the metabolite (MHD) . The mechanism of action of oxcarbazepine and MHD is thought to be mainly based on the blockade of voltage-sensitive sodium channels, thus resulting in stabilisation of hyperexcited neural membranes, inhibition of repetitive neuronal firing, and diminishment of propagation of synaptic impulses. In addition, increased potassium conductance and modulation of high-voltage activated calcium channels may also contribute to the anticonvulsant effects. No significant interactions with brain neurotransmitter or modulator receptor sites were found.
Trioptal Tablets Usage And Safety
Dosage
Oxcarbazepine
Side Effects
Very common (may affect more than 1 in 10 people): • tiredness; headache; dizziness; drowsiness; feeling sick (nausea); being sick (vomiting); double vision. Common (may affect up to 1 in 10 people): • weakness; memory disturbances; impaired concentration; apathy; agitation; confusion; blurred vision; visual disturbance; constipation; diarrhoea; stomach (abdominal) pain; acne; hair loss, balance disturbances; weight increased; speech disorder. Uncommon (may affect up to 1 in 100 people): • High blood pressure; hives. • You may also have raised levels of liver enzymes while taking oxcarbazepine.
Drug Interactions
Hormonal contraceptives, such as the pill , Other antiepileptic and enzyme inducing medicines, such as carbamazepine, phenobarbital, phenytoin or lamotrigine and rifampicin , diuretics , desmopressin , indometacin , Lithium and monoamine oxidase inhibitors , ciclosporin and tacrolimus.
Indication
It is used to treat partial seizures with or without secondarily generalised tonic-clonic seizures.
When not to Use
Do not take If you are allergic to oxcarbazepine or any of the other ingredients of this medicine or if you are allergic to eslicarbazepine.
Trioptal Tablets Precautions
Precaution
Hypothyroidism is an adverse reaction (with “uncommon” frequency, of oxcarbazepine. Considering the importance of thyroid hormones in children's development after birth, thyroid function monitoring is recommended in the pediatric age group while on oxcarbazepine therapy.
Trioptal Tablets Warnings
Warning 1
Class I (immediate) hypersensitivity reactions including rash, pruritus, urticaria, angioedema and reports of anaphylaxis have been received in the post-marketing period. Cases of anaphylaxis and angioedema involving the larynx, glottis, lips and eyelids have been reported in patients after taking the first or subsequent doses of Oxcarbazepine. If a patient develops these reactions after treatment , the drug should be discontinued and an alternative treatment started.
Warning 2
Very rare cases of hepatitis have been reported, which in most cases resolved favourably. When a hepatic event is suspected, liver function should be evaluated and discontinuation of oxcarbazepine should be considered. Caution should be exercised when treating patients with severe hepatic impairment.
Warning 3
Discontinuation of the medicinal product should be considered if any evidence of significant bone marrow depression develops.
Trioptal Tablets Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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