SEARLE PAKISTAN
Spiromide Tablets 40Mg
Spiromide Tablets 40Mg
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SPECIFICATION
Requires Prescription (YES/NO)
Yes
Generics
Furosemide , Spironolactone
Used For
Heart Failure
How it works
Furosemide: Furosemide is a short-acting diuretic; diuresis usually commences within one hour and lasts for four to six hours. Spironolactone: Spironolactone, a competitive inhibitor of aldosterone, increases sodium excretion whilst reducing potassium loss at the distal renal tubule. It has a slow and prolonged action; maximum response being usually attained after 2 – 3 days treatment.
USAGE AND SAFETY
Dosage
Furosemide , Spironolactone
Side Effects
Blood and lymphatic system disorders : Not known: Bone marrow depression has been reported as a rare complication and necessitates withdrawal of treatment ; Nervous system disorders : Not known: Paraesthesia may occur , Dizziness, fainting and loss of consciousness (caused by symptomatic hypotension), headache. Renal and urinary disorders : Not known: Serum calcium levels may be reduced; in very rare cases tetany has been observed. Nephrocalcinosis / Nephrolithiasis has been reported in premature infants ; Increased production of urine may provoke or aggravate complaints in patients with an obstruction of urinary outflow.
Drug Interactions
Potassium supplements such as potassium chloride or certain water tablets (diuretics) such as triamterene and amiloride , ramipril, enalapril, perindopril (called ‘ACE inhibitors’) or losartan, candesartan, irbesartan , Theophylline , Phenytoin , Trimethoprim and trimethoprimsulfamethoxazole , Lithium , Cisplatin , Digoxin , aspirin, ibuprofen, ketoprofen or indometacin , Carbamazepine , Aminoglutethimide , Ciclosporin , Methotrexate , Carbenoxolone , Corticosteroids , Probenecid , Cholestyramine , gentamicin, amikacin, neomycin, netilmicin, tobramycin, vancomycin or high doses of cephalosporins , salbutamol, terbutaline sulphate, salmeterol, formoterol or bambuterol) , Reboxetine , Amphotericin , bisacodyl or senna , Liquorice .
Indication
It is indicated in the treatment of resistant oedema where this is associated with secondary hyperaldosteronism; conditions include chronic congestive cardiac failure and hepatic cirrhosis .
When not to Use
• You are allergic (hypersensitive) to furosemide, spironolactone or any of the other ingredients. Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue. You are allergic to sulphonamides such as sulfadiazine or co-trimoxazole. • You have severe problems with your kidneys. • You have severe liver problems. • Your doctor has told you that you have a low blood volume or are dehydrated.
PRECAUTIONS
Precaution
Urinary outflow must be secured. In patients with a partial obstruction of urinary outflow (e.g. in patients with bladder-emptying disorders, prostatic hyperplasia, prostatic hypertrophy or narrowing of the urethra), increased production of urine may provoke or aggravate complaints (such as risk of developing acute retention). Thus, these patients require careful monitoring, especially during the initial stages of treatment.
WARNINGS
Warning 1
Treatment with Lasilactone necessitates regular medical supervision. Particularly careful monitoring is necessary in patients with hypotension or patients liable to electrolyte deficiency. Where indicated, steps should be taken to correct hypotension or hypovolaemia before commencing therapy.
Warning 2
Regular monitoring of serum sodium, potassium, creatinine and glucose is generally recommended during therapy; particularly close monitoring is required in patients at high risk of developing electrolyte imbalances or in case of significant additional fluid loss (e.g. due to vomiting, diarrhoea or intense sweating). Hypovolaemia or dehydration as well as any significant electrolyte and acid-base disturbances must be corrected. This may require temporary discontinuation of Lasilactone.
Warning 3
dministration of Lasilactone should be avoided in the presence of a raised serum potassium. Frequent checks of the serum potassium level are necessary in patients with impaired renal function and a creatinine clearance below 60 ml/min per 1.73 m2 body surface area as well as in cases where Lasilactone is taken in combination with certain other drugs (e.g. triamterene, amiloride, potassium supplements or non-steroidal anti-inflammatory drugs) which may lead to an increase in potassium levels.
ADDITIONAL INFORMATION
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.