NOVARTIS PHARMA (PAK) LTD
Simbrinza Eye Drops 5ml
Simbrinza Eye Drops 5ml
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Simbrinza Eye Specification
Requires Prescription (YES/NO)
Yes
Generics
Brinzolamide , Brimonidine tartrate
Used For
Glaucoma
How it works
It contains two active substances: brinzolamide and brimonidine tartrate. These two components lower intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) and ocular hypertension (OHT) by suppressing the formation of aqueous humour from the ciliary process in the eye. Although both brinzolamide and brimonidine lower IOP by suppressing aqueous humour formation, their mechanisms of action are different.Brinzolamide acts by inhibiting the enzyme carbonic anhydrase (CA-II) in the ciliary epithelium that reduces the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport across the ciliary epithelium, resulting in decreased aqueous humour formation. Brimonidine, an alpha-2 adrenergic agonist, inhibits the enzyme adenylate cyclase and suppresses the cAMP-dependent formation of aqueous humour. Additionally, administration of brimonidine results in an increase in uveoscleral outflow.
Simbrinza Eye Usage And Safety
Dosage
Brinzolamide , Brimonidine tartrate
Side Effects
Somnolence , dermatitis , dry throat , hypotension , vertigo , blurred vision , bad taste .
Drug Interactions
MAOIs , oral carbonic anhydrase inhibitors , high-dose salicylate therapy , CNS depressants , antihypertensives/cardiac glycosides , tricyclic antidepressants .
Indication
It is used to lower pressure in the eyes in adult patients (aged 18 years and over) who have eye conditions known as glaucoma or ocular hypertension and whose high pressure in the eyes cannot be controlled effectively by one medicine alone.
When not to Use
Don't use if you are allergic to brinzolamide or brimonidine tartrate or any of the other ingredients of this medicine .
Simbrinza Eye Precautions
Precaution
Brimonidine tartrate may cause ocular allergic reactions. If allergic reactions are observed, treatment should be discontinued. Delayed ocular hypersensitivity reactions have been reported with brimonidine tartrate, with some reported to be associated with an increase in IOP.
Simbrinza Eye Warnings
Warning 1
It should be used with caution in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension or thromboangiitis obliterans.
Warning 2
It contains brinzolamide, a sulphonamide inhibitor of carbonic anhydrase and, although administered topically, is absorbed systemically. The same types of adverse reactions that are attributable to sulphonamides may occur with topical administration. If signs of serious reactions or hypersensitivity occur, the use of this medicinal product should be discontinued.
Warning 3
It should be used with caution in patients with risk of renal impairment because of the possible risk of metabolic acidosis. It is contraindicated in patients with severe renal impairment .
Simbrinza Eye Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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