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Ruling+ Sachets 40Mg
Ruling+ Sachets 40Mg
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SPECIFICATION
Requires Prescription (YES/NO)
Yes
Generics
Omeprazole + Sodium Bicarbonte
Used For
Gastroesophageal Reflux Disease
How it works
Omeprazole reduces gastric acid secretion through a unique mechanism of action. Omeprazole belongs to a class of anti-secretory compounds - the substituted benzimidazoles that do not exhibit anti-cholinergic or H2 histamine antagonistic properties. It inhibits secretion of gastric acid by irreversibly blocking the enzyme system of hydrogen/potassium adenosine triphosphatase (H+/K+ATPase), the proton pump of the gastric parietal cell. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.
USAGE AND SAFETY
Dosage
Omeprazole + Sodium Bicarbonte
Side Effects
Common : Central and peripheral nervous system: Headache. Gastrointestinal: Diarrhea, constipation, abdominal pain, nausea/vomiting and flatulence.Uncommon : Central and peripheral nervous system: Dizziness, paraesthesia, somnolence, insomnia and vertigo.Hepatic: Increased liver enzymesSkin: Rash and/or pruritis, urticariaOther: MalaiseRare : Central and peripheral nervous system: Reversible mental confusion, agitation,aggression, depression and hallucinations, predominantly in severely ill patients.Endocrine: Gynecomastia
Drug Interactions
Ketoconazole and itraconazole , diazepam, citalopram, imipramine, clomipramine, phenytoin , Atazanavir , Digoxin , Clopidogrel , posaconazole, erlotinib , Saquinavir , Tacrolimus , Methotrexate , clarithromycin , CYP2C19 or CYP3A4 or both (such as rifampicin and St John's wort.
Indication
It (Omeprazole) is indicated in adults for the treatment of: Gastro-Esophageal Reflux Disease (GERD):- Treatment of erosive reflux esophagitis.- Long term management of patients with healed esophagitis to prevent relapse.- Symptomatic treatment of gastroesophageal reflux disease (GERD).
When not to Use
Omeprazole is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted benzimidazoles. Omeprazole must not be used concomitantly with nelfinavir.
PRECAUTIONS
Precaution
Symptomatic response to therapy with omeprazole does not preclude the presence of gastric malignancy .
WARNINGS
Warning 1
Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with omeprazole .
Warning 2
Sodium bicarbonate should be used with caution in patients with Bartter's syndrome, hypokalemia, respiratory alkalosis, and problems with acid-base balance. Long- term administration of bicarbonate with calcium or milk can cause milk-alkali syndrome .
Warning 3
Omeprazole powder for oral suspension contains sodium in the form of sodium bicarbonate. This should be taken into consideration for patients on a sodium restricted diet .
ADDITIONAL INFORMATION
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.