Xenon Pharmaceuticals (PVT) LTD
Xenon Pharmaceuticals (PVT) LTD
Xenon Pharmaceuticals (PVT) LTD
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SPECIFICATION
Requires Prescription (YES/NO)
Yes
Generics
Phenobarbitone
Used For
Epilepsy
How it works
Phenobarbitone acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenobarbitone may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release.
USAGE AND SAFETY
Dosage
Phenobarbitone
Side Effects
Drowsiness , ataxia , allergic skin reactions , paradoxical excitement , irritability , hyperactivity and confusion , megaloblastic anaemia . Restlessness and confusion in the elderly . Hyperkinesia in children . Tolerance and dependence lethargy , nystagmus , respiratory depression , hallucinations , memory and cognitive impairment , behavioural disturbances , depression , agranulocytosis , thrombocytopenia , hepatitis , cholestasis , osteomalacia , hypotension.
Drug Interactions
Coumarin anticoagulants , alcohol and other CNS depressants , oral contraceptives , griseofulvin , rifampicin , phenytoin , metronidazole , doxycycline , chloramphenicol , telithromycin , antidepressants , St.John's wort , antipsychotics , nucleoside reverse transcriptase inhibitors , protease inhibitors , eplerenone , voriconazole , other anticonvulsants , digoxin , folic acid , methylphenidate .
Indication
It is used as sedative , anticonvulsant .
When not to Use
Hypersensitive to any of the ingredients in the list.
Precaution
A small number of people being treated with anti-epileptics such as phenobarbitone have had thoughts of harming or killing themselves. If at any time you have these thoughts, immediately contact your doctor.
Warning 1
Potentially life-threatening skin rashes (Stevens-Johnson syndrome, toxic epidermal necrolysis) have been reported with the use of Phenobarbitone, appearing initially as reddish target like spots or circular patches often with central blisters on the trunk.
Warning 2
These potentially life-threatening skin rashes are often accompanied by flu-like symptoms. The rash may progress to widespread blistering or peeling of the skin.
Warning 3
The highest occurence of serious skin reactions is within the first week of treatment. If you have developed Stevens-Johnson syndrome or toxic epidermal necrolysis with the use of Phenobarbitone, you must not be restarted on Phenobarbitone at any time.
ADDITIONAL INFORMATION
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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