Obs Pakistan Pvt. Ltd
Co-Renitec Tablets 10Mg/25Mg
Co-Renitec Tablets 10Mg/25Mg
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SPECIFICATION
Requires Prescription (YES/NO)
Yes
Generics
Enalapril Maleate + Hydrochlorothiazide
Used For
Hypertension
How it works
Enalapril maleate : Enalapril, after hydrolysis to enalaprilat, inhibits angiotensin-converting enzyme (ACE). The mechanism through which enalapril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion. In patients treated with enalapril maleate plus a thiazide diuretic, there was essentially no change in serum potassium. Hydrochlorothiazide : Hydrochlorothiazide is a thiazide diuretic. It affects the distal renal tubular mechanism of electrolyte reabsorption. Hydrochlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate.
USAGE AND SAFETY
Dosage
Enalapril Maleate + Hydrochlorothiazide
Side Effects
• Headache, depression, fainting • low blood pressure (which may make you feel dizzy when you stand up) • chest pain • heart rhythm changes, fast heart beat • shortness of breath • diarrhoea, pain around your stomach area (abdomen), changes in taste, feeling tired • rash • increased blood potassium level, increases in serum creatinine (both are usually detected by a test) • low levels of potassium in the blood, which can cause muscle weakness, twitching or abnormal heart rhythm, increased levels of cholesterol, increased levels of triglycerides, increased levels of uric acid in the blood • muscle cramps.
Drug Interactions
Sirolimus, everolimus , potassium sparing ‘water tablets’ (diuretics) such as spironolactone, eplerenone, triamterene or amiloride, potassium supplements, or potassium-containing salt substitutes , ‘water tablets’ (diuretics such as thiazides, furosemide, bumetanide), nitroglycerine, nitrates, vasodilators, methyldopa and angiotensin II receptor antagonists (e.g. candesartan, irbesartan and losartan) , lithium , barbiturates , phenothiazines , cholestyramine or colestipol , corticotropin , probenecid, sulfinpyrazone and allopurinol , ciclosporin , procainamide, amiodarone, sotalol, quinidine, hydroquinidine, disopyramide, dofetilide oributilide , digitalis , carbenoxolone , carbamazepine , amphoteracin B .
Indication
It is used to treat Hypertension.
When not to Use
Do not take Enalapril Maleate and Hydrochlorothiazide: • If you are allergic to enalapril, hydrochlorothiazide or any of the other ingredients of this medicine • If you have severe kidney problems • If you are not passing urine • If you have previously suffered from swelling of the extremities, face, lips, throat, mouth or tongue (angioedema) when treated with other ACE inhibitors such as ramipril or under any other circumstances .
PRECAUTIONS
Precaution
If hypotension occurs, the patient should be placed in a supine position and if necessary, should receive an intravenous infusion of normal saline. A transient hypotensive response is not a contra-indication to further doses, which can usually be given without difficulty once the blood pressure has increased after volume expansion.
WARNINGS
Warning 1
If you have a kidney problem (including kidney transplantation). These may lead to higher levels of potassium in your blood which can be serious. Your doctor may need to adjust your dose of Enalapril or monitor your blood level of potassium.
Warning 2
If you have low blood pressure (you may notice this as faintness or dizziness, especially when standing) .
Warning 3
If you have diabetes and are taking antidiabetic agents or insulin to control your diabetes; you should closely monitor your blood for low blood glucose levels especially during the first month of treatment. The level of potassium in your blood can also be higher.
ADDITIONAL INFORMATION
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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