MASS PHARMA (PVT) LTD
Pat-4 Oral Tablets
Pat-4 Oral Tablets
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SPECIFICATION
Requires Prescription (YES/NO)
No
Generics
Glucosamine Sulphate ,Chondroitin Sulphate Sodium , Hyaluronic Acid
Used For
Bones & Joints Care
How it works
Glucosamine : Glucosamine is a normal constituent of polysaccharide chains of cartilage matrix and synovial fluid glucosaminoglycans. It stimulates the synthesis of physiological glycosaminoglycans and proteoglycans by chondrocytes and hyaluronic acid by synoviocytes. Glucosamine Sulfate also inhibits the activity of cartilagedestroying enzymes such as collagenase and phospholipase A2, as well as the generation of other tissue damaging substances such as superoxide radicals or the activity of lysosomal enzymes that contributes to its mild anti-inflammatory effects. Chondroitin Sulfate Sodium : Chondroitin Sulfate increases the synthesis of cartilage matrix components such as hyaluronic acid and proteoglycans and reduces the degradation of cartilage matrix components, specifical ly col lagen II, glycosaminoglycans and proteoglycans, and reduces necrosis and apoptosis of chondrocytes. Chondroitin Sulfate also reduces the activity of collagenase, Nacetylglucosaminidase, aggrecanase 1 and 2, matrix metalloproteinase (MMP) 3, MMP-9, MMP-13, MMP-14, cathepsin B and elastase and elicits an anti-inflammatory effect through diverse mechanisms.
USAGE AND SAFETY
Dosage
Glucosamine Sulphate ,Chondroitin Sulphate Sodium , Hyaluronic Acid
Side Effects
Glucosamine: Nausea, diarrhea, epigastric pain/ tenderness, constipation, dyspepsia, indigestion, heartburn, headache, abdominal pain, palpitation, drowsiness, somnolence and skin reactions. Chondroitin Sulfate Sodium: Nausea, diarrhea, mild stomach pain, constipation, swollen eyelids, hair loss, leg swelling, heart burn and irregular heartbeat. Hyaluronic Acid : Bruising , Sore injection site , Swelling , Formation of tiny, generally temporary bumps.
Drug Interactions
Coumarins anticoagulants, blood pressure medicines , NSAIDs, hypoglycemic agents.
Indication
It is used as a dietary supplement: - To relieve pain and improve function in patients with mild to moderate osteoarthritis - In joint pain - In cartilage degeneration - In tendonitis - In bursitis .
When not to Use
It is contraindicated in: - Patients with hypersensitivity to any of the ingredients of the product. - Patients with shellfish allergy. - Patients with prostate cancer or are those that are at high risk of developing it . - Children and adolescents under the age of 18 years .
PRECAUTIONS
Precaution
In patients with impaired glucose tolerance , monitoring of the blood glucose levels and where relevant , insulin requirements is recommended before start of treatment periodically during treatment.
WARNINGS
Warning 1
Asthma symptoms may exacerbate after initiation of Glucosamine and Chondroitin Sulfate therapy . Caution should be exercised during treatment in patients with pre-existing asthma.
Warning 2
Administration of this product to patients with severe hepatic or renal insufficiency should be under appropriate medical supervision.
Warning 3
The use of Glucosamine and Chondroitin Sulfate is not recommended during breast feeding .
ADDITIONAL INFORMATION
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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